PYH Newsletter: How to Make Your Estradiol or Biest Cream Work Better


Dr. Valorie

September 30th, 2026

How to Make Your Estradiol or Biest Cream Work Better

In this issue


How to Make Your Estradiol or Biest Cream Work Better


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Simon Says


My Menopause

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How to Make Your Estradiol or Biest Cream Work Better​
Dr. Valorie Davidson

‘I’m still having hot flashes’

‘I’m still having anxiety’

‘I’m still not sleeping well through the night’

‘I feel so crabby and irritable’

‘My brain fog is still bad’

‘Why isn’t my hormone cream working!!?’​
​

Well, there are many reasons that your HRT might not be working for you. It could be the dose, timing, and/or absorption.

So for this article, I’m going to give you some hacks on how to get your HRT cream to work better.

Background on what is Estradiol and Biest:

Estradiol cream and Bi-Est are both compounded topical hormone options, but they are not the same thing.

  • Estradiol cream contains estradiol (E2)
  • Biest combines estriol (E3) with estradiol (E2)

Both Bi-Est and estradiol gel/cream are transdermal HRT options that are applied to the skin. But not everyone absorbs topical estrogen the same way. This means the same dose can result in very different estrogen exposure from one woman to another, which may help explain why one woman feels great on a particular dose while another continues to experience low-estrogen symptoms.

4 Hacks to Get Your Estradiol or Biest Cream to Work Better

Compounded estradiol cream and estradiol gels behave very differently than an estradiol patch.

  • Side note: Creams and gels differ in several ways. The base, if there is alcohol content, excipients, concentration, and other formulation characteristics can all influence how estradiol is absorbed through the skin. That’s a whole topic on its own.

For this, though, we’ll look at creams and gels together as transdermal estradiol preparations.

4 hacks you can do to help your transdermal estradiol absorb more consistently and work better.

  1. Location, Location, Location:
    1. Estradiol is lipophilic, meaning fat-loving. That is partly what makes estradiol so well suited to transdermal delivery.
    2. I like to find a soft area of skin that has a little fat tissue. It’s not just about the fat, but about the skin, most importantly. Estradiol moves through the layers of the skin into circulation.
    3. In my clinical experience, the thigh, inner thigh, and back of the knee seem to be some of the best places. And also, most importantly, these areas keep you from “sharing” your hormones or having them get on pets and kids.
    4. Do not apply to breast tissue. And I do not like the abdomen or stomach bc I don’t want the cream to migrate anywhere near the breast tissue. Bc that can cause hyperproliferation of the breast tissue and breast tenderness.
  2. Concentrate, Don’t Slather (Surface Area Matters):
    1. Don’t treat your hormone cream like lotion and put it all over.
    2. I mentioned that I like applying estradiol/biest to the inner thigh. But don’t rub it all over the inner thigh. Keep it to one small concentrated area.
    3. Why? Spreading your estradiol cream over a large surface area can dilute the estradiol concentration and reduce its ability to penetrate the tissues.
    4. Keep the application area small and rub very well until there seems to be no cream left. This can take a good 20 seconds or more, but it is a great way to get that concentration of estradiol into your system.
    5. Wash your hands after application, so you don’t share it with anyone else.
    6. I have seen people put their hormones on the sheets or towels, and it gets on others. So head to the sink and wash with soap so you don’t share your estradiol.
  3. The Heat Is On!
    1. Apply your estradiol/biest cream to warm skin.
    2. Warm skin has dilated blood vessels and increased blood flow, which means better absorption of your estradiol cream.
    3. Apply your cream right after a warm shower when your skin is 100% dry.
    4. Or you can rub and tap your skin to get that heat and blood flow moving. That is why I like the inner thigh as an application site, since it's a nice warm area.
  4. Don’t Wash or Wipe it off:
    1. If you are going to shower, go swimming or even goto the gym where you will get really sweaty, wait at least an hour. Two hours is perfect, but one hour is just fine too, especially if you really rubbed the cream into the skin in a small surface space.
    2. Make sure the cream is well rubbed in. If it is just sitting on the skin and you put your clothes on, then you share it with your clothes. Make sure you take time to really rub that cream all the way before dressing.

Additional Tips for Making Your Estradiol/Biest Work Better:

Bc there is so much more than just four hacks.

  • BID: Only For Compounded Estradiol or Biest
    • Apply your estradiol dose twice a day. It doesn’t have to be exactly 12 hours apart, but once in the morning and again in the evening.
    • If you apply it once a day, it will be mostly out of your system 10-14 hours later. Which is why women wake up in the middle of the night with the nightsweat and/or hot flashes.
  • My Doc Says My Blood Work Is Fine. But I Am Still Getting Hot Flashes At Night!
    • This is for compounded estradiol and biest creams.
    • Feeling fine during the day, but hit 1-3 am and you are waking up tossing the covers off?
      • Sometimes, women need a little more estradiol at night than in the morning to keep the hot flashes at bay. So your evening dose may be a little more than your morning.
    • Getting a doozy of a hot flash at 5-7am about the time to wake up for the day?
      • Apply your estradiol cream right before bed, as soon as you are ready to fall asleep.
      • Sometimes if you put it on say at 8pm, by 5am, your level may have dropped. So put it on right before bed.
      • ​

What If you’re doing all of this correctly and you’re STILL not feeling well?

Maybe you’re still having hot flashes, poor sleep, brain fog, joint pain, or other symptoms despite using your HRT consistently.

In the paid version, I’ll show you how to look beyond application technique and dig deeper into why your estradiol or Bi-Est may not be working.

Upgrade to continue reading and get access to all of my paid hormone newsletters.

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Simon Says:

Stand on one leg for 30 seconds.

Then switch legs. And try it without holding onto anything.

Balance is one of those things we don’t think about until we start losing it. Practicing it helps train your muscles and nervous system to react quickly when you stumble, trip, or suddenly lose your footing.

And I am way better at standing on my left leg than right. I better get to practicing!


My Menopause

Menopause and My Mouth!

I have to go to the dentist soon. I know we need to keep our dental hygiene up and go to all the cleanings. But every so often my dentist says I need to do some kind of deep cleaning to prevent periodontal disease or something like that. Where they numb your mouth and clean one side and then I come back a couple days later to do the other side.

I’ve never had to do that when I was younger.

Is it bc I’m older? I’m aging? I have more $ to spend at the dentist? Or is it my menopause?

There are studies that have found postmenopausal women tend to have more gum inflammation, deeper pockets around the teeth, and a greater risk of periodontal problems.

Estradiol can influence everything from the tips of our toes to the top of our head. But while we are focusing on joint pain, sleep, weight, libido, brain fog, and all the ‘things’ that go with menopause, what about your mouth? Can lower estradiol levels change your teeth, gums, and oral health?

Low Estradiol Can Influence Salivary Gland Function

Salivary glands contain estrogen receptors. So it makes sense that lower estradiol may have a potential impact on oral health.

  • Declining estradiol has been associated with:
    • Salivary flow
    • Salivary composition
    • Dry mouth

But it's not as simple as low estradiol means less saliva. While it can occur as less saliva production, not every menopausal woman has dry mouth or less saliva.

Saliva composition can change in menopause, affecting oral health. It’s the quality of the saliva that can impact oral health.

Saliva Is Not Just “Spit”

Saliva is about 99% water, but the remaining 1% is packed with biologically active components.

  • Electrolytes/minerals (like calcium and phosphate) to help remineralize early enamel damage
  • Bicarbonate to maintain a healthy oral pH
  • Proteins and glycoproteins to lubricate and protect your oral tissues
  • Antimicrobial components
  • Enzymes like amylase, which begins digestion of starches
  • Growth factors and other signaling molecules
  • Of course, saliva physically washes away debris

So saliva isn't just water. It’s a mineral-rich, buffered biological fluid that continuously protects your teeth and oral tissues.

Again, What Does Estradiol Have to Do with Saliva?

You may have less saliva (but not always), which reduces saliva's benefits.

The main issue is that declining estradiol levels can affect salivary gland function, which in turn affects salivary composition and, in turn, saliva's benefits.

↓ Estradiol → changes in salivary gland function → changes in saliva flow and composition → reduced protective benefits of saliva → less protection for teeth and oral tissues

So What Happens When the Estradiol Drops?

As estradiol declines, some women may start to experience:

  • Dry mouth
  • Increased risk for cavities
  • More plaque buildup
  • Bad breath
  • Gum irritation, inflammation, or bleeding
  • Increased risk of periodontal disease
  • Burning mouth syndrome (this is complex and not always just about estradiol)

Aside from “Spit”... Declining estradiol can affect your bones around your teeth.

Periodontal tissues have estrogen receptors. So as estradiol levels decline, estrogen signals to the gums and periodontal tissues can change. Making the gums more susceptible to irritation, bleeding, and periodontal disease. And with time, this can lead to:

  • Gum recession
  • Loss of supporting bone around the teeth
  • In severe cases, tooth loss

Don’t Forget About Your Mouth

During menopause and the decline of estrogen, even in late perimenopause, your mouth is responding to those changes too. It can affect your saliva, gums, periodontal tissues, the bone supporting your teeth, and even cause stinky breath.

Now, your teeth didn’t suddenly become high-maintenance. But I sure didn’t floss this much, brush this much, buy expensive toothbrushes, or even know what a Waterpik was in my 20s. But now, in my 50s, I know HRT is part of my oral-health picture.

Xo Dr. Valorie

Disclaimer

All content found in this newsletter, including text, images, audio, video, or other formats, was created for informational purposes only. The purpose of this website and blog is to promote consumer/public understanding and general knowledge of various health topics. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concern regarding this topic, then it is time to find a new doctor.

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