PYH Newsletter: The Thanksgiving Effect


Dr. Valorie

November 25th, 2025

The Thanksgiving Effect

In this issue

What's Happening


The Thanksgiving Effect


Simon Says


My Menopause

What's Happening?

Hi everyone,

I’ve made a free video minicourse called The In-Betweener Minicourse. It’s for anyone who is almost out of perimenopause but not quite in menopause, where you feel stuck in the middle. This phase in life is often overlooked, misdiagnosed, and/or mistreated. If this sounds like you, just click on the link.

xodrvalorie

This is newsletter #18!

If you missed any of the newsletters, check out the Progress Your Hormones Newsletter Archive.

I do not have AI write my articles.

Why?

Bc I like spending hours writing.

Bc AI does not sound like me and I hate the werid dashes it puts in

Bc I find AI is not accurate (seriously, you need to fact check anything you ask AI)

Bc my AI tends to coddle me

Bc I just don’t feel like it is authentically me.

- Xo DrValorie


The Thanksgiving Effect

Spoiler: It Can Kill You

Dr. Valorie Davidson

It’s the tryptophan. It sure is.

That is why you are sleepy after your Turkey dinner.


There’s a lot of tryptophan in turkey. And tryptophan makes you drowsy, right?


Tryptophan → 5-HTP → Serotonin → Melatonin = Zonked Out


Yes, that is the explanation that after your Thanksgiving meal, you are ready for sleepy-time.


Or is it?


In the United States, many readers (including some from around the world) are familiar with Thanksgiving. I know, I know, there is an insidious side to Thanksgiving's history, which we could discuss for hours, weeks, or years...


Currently, I like to think of Thanksgiving as:

  • Gratitude
  • Family and friend gatherings
  • A moment to pause
  • Food and tradition
  • Togetherness before the holiday rush

This is what I like to call ‘The Thanksgiving Effect’.


Sure, it's fun for the day and the day after bc of the leftover fixings.


But sadly, in this country (and perhaps others), the Thanksgiving Effect is in full swing year-round.

And that is what is contributing to the many chronic conditions and metabolic dysfunction that reduce quality of life and ultimately a shortened lifespan.


Trust me, I like a bowl of ice cream and look longingly at the bags upon bags of chips in the grocery store.


The companies that manufacture these ‘goods’ are brilliant. With their food-scientists, flavor-chemists, and sensory panels (testing humans as lab-rats), they create foods that are irresistible to our palates.


They even research and develop foods that have a particularly pleasing ‘mouth-feel’, like crunchy, smooth textures that, plain and simple, feel good.


Our biology, brains, and bodies are just doing what we were made to do: seek out sugar, fat, and salt.


They make food with the intention to ‘overeat’. Overeat = $$$


I mean, when did a box of cereal from my childhood cost like six bucks or a bag of chips, eight bucks? I thought those foods were supposed to be cheap.


Just like drug dealers, once you're hooked, you will pay.


Okay, okay, I will get off my soapbox. However, it can be challenging to avoid ultra-processed, processed foods and added sugars.


Knowledge is power (back on my soapbox, it seems).


If you understand what is happening in your body, you can reclaim your power and create a healthier life.


In this article, I will break down the ‘Thanksgiving Effect’ and provide you with some manageable tools to help stop the cycle. Maybe not on actual Thanksgiving, bc please enjoy the festivities. But the entire year doesn’t need to be a Thanksgiving feast.


Let’s look at this from our Thanksgiving meal. For some of us, that is in a couple of days.


Carbohydrates become Sugar (glucose):

  • Mashed potatoes
  • Stuffing
  • Cranberries (my mother is horrified that I like the canned ones)
  • Rolls
  • Dessert (The pies! pumpkin, pecan, sweet potato, apple…and you gotta have it with ice cream and whipping cream)

Put all of these together, and you have a glucose tsunami!


Your blood sugar shoots through the atmosphere, and your pancreas says, “I’m coming to the rescue!”.


The Pancreas is my Hero:


All that blood sugar (glucose) needs to get out of our bloodstream and go…somewhere. Anywhere but your bloodstream.


Because when glucose hangs around too long in the blood, it:

  • Damages blood vessel walls
  • Stiffens tissues
  • Inflames the cardiovascular system
  • Increases oxidative stress
  • Inflammation
  • Gut dysbiosis

Meaning it can increase risk for diabetes, cancer, heart disease, and dementia.


Back to the pancreas. Your pancreas is going to pump out a ton of insulin to pull all the sugar out of your bloodstream.


The insulin is like a key. It will unlock the door on your cells and push glucose inside.


Where does the glucose go?

  • Glycogen in your muscles = fuel storage
  • To your liver = overtime and excess glucose can cause fatty liver
  • Hips, thighs, and belly = superficial fat
  • Visceral fat = fat wrapped around your organs (which is very inflammatory)

CRASH! POW! ZAP!
After all that glucose is pushed out of your bloodstream, your blood sugar crashes.

  • Sleepy
  • Foggy
  • Don’t want to move feeling (aka: don’t want to be part of the cleanup crew)

Liver Working Overtime:
While your pancreas is trying to get all that glucose out of your bloodstream, your liver is busy at work trying to put the sugar away by:

  • Storing excess glucose as glycogen
  • Converting glucose to fat
  • Filtering alcohol
  • Processing the fructose from dessert
  • Generally, dealing with inflammatory food additives and other toxins.

But it’s so much FUN!

These foods (and the massive quantities of them) cause MASSIVE dopamine spikes.

Dopamine makes us feel good and want to do that ‘feel-good thing’ again, and again, and again.

Bring on the rush, the high, the reward…

Dopamine is such a fickle friend.

Dopamine hits fast, but drops fast.

So you are eating and feeling good. Then you want a little more (even though you're full). And a little more, and you keep coming back for more.

Hence, ‘I’m stuffed… Are there any more potatoes?’

Dopamine and Insulin = Bad Influence Friends

You eat the yummy food. Enjoy the taste, how it feels in your mouth, it’s soooo good.

That dopamine is flying.

Blood sugar spikes and insulin to the rescue.

Dopamine drops, and you want more. So hey, let’s have some more of that deliciousness.

The Fun Police: Meet Officer Vagus-Nerve

Excuse me, Ms Davidson, I am Officer Vagus Nerve.

Do you know why you are being called out?

I could issue you a citation… Because that dinner you just ate was a felony-level portion.

Instead, I am going to give you a warning.

Warning to halt the huge meals.

Huge meals stretch your stomach.

When that happens, I have to flip on my lights and shut everything else down.

Time to digest, rest, and recover..

Eat safely, and have a good day.


Your vagus nerve is the longest nerve in your body.


Officer Vagus Nerve’s patrol starts in your brainstem and travels down your neck, chest, and stomach.


His jurisdiction touches almost everything:

  • Throat
  • Heart
  • Lungs
  • Esophagus
  • Stomach
  • Liver
  • Pancreas
  • Intestines

When you eat a big meal, your stomach expands. This expansion stimulates stretch receptors, which send signals to the brain via the vagus nerve. This turns on “REST and DIGEST” mode.

The brainstem responds by activating the parasympathetic system:

  • Heart rate slows
  • Blood pressure lowers
  • Energy is diverted away from muscles and the brain
  • Digestion becomes the priority

This is why eating a big meal can make you:

  • Sleepy
  • Foggy
  • Low energy
  • Want to lie down (even nap)

Think, your classic post-carb-heavy lunch crash.

Shut everything down. We’re digesting.

Hope I didn’t just ruin Thanksgiving, sorry.


What Can We Do?

Holidays and Thanksgiving are one thing. But as I said above, living every day like it’s Thanksgiving is actually pretty commonplace.

It’s biology we are fighting here.

  • Yummy processed foods filled with sugar, fat, and salt. Foods that are almost irresistible in large quantities at one time.
  • Spike in glucose
  • Spike in dopamine
  • Spike in insulin
  • Crash in sugar and dopamine
  • Officer Vagus Nerve turns on rest/digest
  • Crash in energy, mood, motivation
  • Gimme more

And what can this vicious cycle lead to?

  • Diabetes
  • Weight gain
  • Visceral inflammatory fat (adipose tissue)
  • Cancer
  • Dementia (brain health)
  • Cardiovascular disease

Again, WHAT CAN WE DO ABOUT IT?

Like I said, I hope I didn’t ruin Thanksgiving for you.

Enjoy the holidays.

Enjoy family, friends, even the peace of solitude that can come with the world standing still on a national (U.S) holiday.

I just wanted to show you how we can avoid the pitfalls of this ‘New World’ designed for endless sugar, ginormous portions, and dopamine-engineered foods.

Take care,

Dr.Valorie


Want to learn what to do with lifestyle, foods, sleep, and supplementation? Upgrade to the paid version (9$/mo with access to all past paid issues).

If you’d like to dive into the science behind why this happens and what you can actually do about it (including natural hormone, nutrient, and herbal support), join the paid version of the Progress Your Hormones Newsletter.

Upgrade to the full newsletter here and get the rest of the story.

Simon Says:

Simon Says:

If you’re reaching for something sweet after dinner, that is your insulin talking to you. Your blood sugar dropped quickly after your meal, and your body is asking you to bring it back up.Add more protein and fiber to dinner

  • Add more protein and fiber to dinner
  • Smaller portions
  • Eat slow
  • Have more protein during the daytime to offset nighttime cravingst here...

My Menopause

Do any of you notice that as we get ‘older’, our parents get older too?


Well, my parents still think I’m their ‘kiddo’, and probably always will.


But I’ve noticed that there is a subtle role shift happening.


I’m starting to take care of my parents more. Like making my husband move their furniture, making them hire someone for the yard. Getting rid of my dad’s ladders and chainsaw.


After he tried to climb the ladder with the chainsaw to remove tree branches from the thundercloud trees, horrifying.


We start looking out for them as opposed to them looking out for us.


Me as a teen: My parent know nothing (lots of eyerolls)


20s: What they don’t know, won’t hurt them


30s: When did my parents start getting smart?


40s: Who are the aliens that took over my parents? Invasion of the Body Snatchers! They are smart, nice, and fun to hang out with.


50’s me now: They are still fun, but oh my gosh, I am turning into a mother-hen, picking and pecking them.


Now, I am NOT complaining, and certainly I don’t mean to mock them. I am just trying to adjust to this with honor and respect. I want to honor my parents and not act like a nag.


The reason this suddenly came to me recently is that I didn’t realize my dad has MTHFR.


I’m sure you all know what MTHFR is. Those who are not familiar, read newsletter #10 (Mommie Dearest: Thanks for the MTHFR).


He recently had his blood work done, and his homocysteine is high.


MTHFR can cause homocysteine to rise. This can increase the risk for heart disease and cardiovascular events.


There is approximately 30-40% of the population with MTHFR. Those who need methylated B vitamins, and most importantly, should avoid folic acid.


For people with MTHFR, folic acid is poorly converted to methylfolate and can build up to unmetabolized folic acid (UMFA).


High UMFA has been associated with:

  • impaired immune function
  • masking B12 deficiency
  • sluggish detoxification
  • potential inflammation

My dad has eaten cereal twice a day for as long as I can remember. The boxed kind from our childhood, frosted miniwheats, frosted flakes, raisin bran… It's all on top of their refrigerator.


I know it is his fav.


But that didn’t stop me from grabbing the boxes, grabbing his reading glasses (and mine lol), and showing him the ingredient list…FOLIC ACID and fortified flour (which also has folic acid).


It’s 2025, why do cereals STILL have folic acid in them in the United States?

U.S. fortification law: The FDA still requires enriched grain products to be fortified with folic acid.


This has been in place since 1998. This was to reduce neural tube defects. Now we could go on and on about this one.


Why don’t they just use L-Methylfolate instead?

The main reason is money. Folate is expensive to put into the grains. Like way more, think pennies versus dollars.


Plus, folate is unstable. L-methylfolate breaks down in heat, light, oxygen, and moisture. The L-methylfolate would be degraded even before it hit the shelves.

My dad was really disappointed with his cereals. But the labs didn’t lie, his homocysteine is elevated. He is now taking a form of methylated B vitamins with L-methylfolate. And looking for alternative cereals without enriched grain that doesn’t have folic acid in them.


Yes, he is not ready to give up the cereal. And he is having hard-boiled eggs for breakfast as well to get some protein in.


Foods with Folate: (not as tasty as sugar frosted cereals, but way better for you)

  • Dark leafy greens
  • Avocados
  • Beans and lentils
  • Cruciferous veggies (support methylation)
  • Citrus (vit C to support folate absorption)
  • Berries
  • Eggs (natural folate and choline)
  • Nuts/Seeds
  • Beets
  • Liver

Here I am in my 50s, and it feels good to help my parents. While I am trying to do it with grace and respect, when I go over there for Thanksgiving, I’m still going to check the top of the fridge for those cereals:)

Xoxdrvalorie

Disclaimer

All content found in this newsletter, including text, images, audio, video, or other formats, was created for informational purposes only. The purpose of this website and blog is to promote consumer/public understanding and general knowledge of various health topics. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concern regarding this topic, then it is time to find a new doctor.

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A newsletter about hormones, HRT, and Dr. Valorie’s personal experience with menopause and rhythmic dosing.

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