PYH Newsletter: Peptides: Hype, Hope, or Healing


Dr. Valorie

September 30th, 2025

Peptides: Hype, Hope, or Healing?

BPC-157, TB-500, GHK-Cu

Glow and Estriol Stackin

In this issue

What's Happening


Peptides: Hype, Hope, or Healing

  • Controversial Peptides on the Cutting Edge

Simon Says


GLOW Stack and stacking with Estriol


My Menopause

What's Happening?

Progress Your Hormones Community

I have been so excited about our Progress Your Hormones Community, that perhaps I was not clear on what it actually is. This is bc I have had many people ask me, what exactly is it?

  • The Progress Your Hormones Community is our online membership space for women in perimenopause and menopause.
  • Inside, you’ll find live Q&A, communication, and resources led by me (Dr. Valorie) and Dr. Maki
  • Supportive community of women who truly get what you’re going through.
  • It’s a place to learn, connect, and feel supported, no matter where you live
  • It is open to all women that are looking for answers and connection to their hormone journey

It’s a brand new space and so far it has been so much fun getting to know these amazing women.

I love doing our live events, plus group and DM discussion with the members.

If this is something you are interested in, click here for more information.

xoxodrvalorie

Missed a Newsletter? Or want to read any past Progress Your Hormones Newsletter?


Check out our Library: archive of all past newsletters

Newsletter Library

I do not have AI write my articles.

Why?

Bc I like spending hours writing.

Bc AI does not sound like me and I hate the werid dashes it puts in

Bc I find AI is not accurate (seriously, you need to fact check anything you ask AI)

Bc my AI tends to coddle me

Bc I just don’t feel like it is authentically me.

- Xo DrValorie

BPC-157 and TB-500

Controversial Peptides on the Cutting Edge

Peptides are the hot topic in functional medicine right now. Not a week goes by without someone asking me about peptide therapy. For this article, I will discuss peptides, specifically BPC-157 and TB-500.

Now there is controversy because they are not FDA-approved, with limited human studies. And there are no guidelines on human treatment or protocol. In fact, technically, it is intended for research purposes only. What you are reading here is what I have learned through colleagues, education, and my own research.

Hence, I must disclaim that everything you are about to read is for educational purposes only and is not intended as medical advice.

Now to the fun stuff. I am going to talk about:

  • What is BPC-157?
  • What is TB-500?
  • How to take BPC-157
  • How to take TB-500
  • How to stack BPC-157 and TB-500

BPC-157

BPC-157, which stands for Body Protection Compound 157, is a popular peptide. In fact, it is a 15-amino acid fragment originally found in gastric acid.


It suggests that it may have regenerative properties for our muscles, tendons, bones, and even our gut. The underlying interest is the idea that it could also accelerate healing and aid in recovery.


What Does It Do? And How Does It Do It? Here are the thoughts about BPC-157

  • Reduces inflammation and protects cells from damage
    • It helps keep cell membranes intact and neutralizes reactive oxygen species, which can otherwise damage tissues. This can happen especially during injury, exposure to toxins, and even exercise.
    • Turns off the 'alarm signals' or minimizes immune cells from flooding the injury, so there is less swelling and irritation.
    • By damping inflammation and protecting cells, damaged tissue can rebuild more quickly.
  • Promotes healing
    • Promotes new blood vessel growth and protects the vessel lining.
    • Synthesizes collagen by activating fibroblasts to help repair tendons and ligaments.

Essentially, BPC-157 can help silence the 'fire alarm' triggered by an injury, reducing inflammation, and creates temporary shields to protect cells from further damage. And then will coordinate a cleanup crew to increase blood vessels and collagen for faster repair response.

The big question is, can BPC-157, taken as a peptide, help our own injury response and accelerate healing?

How Does BPC-157 Help Our Bones, Tendons, Muscles, and Even Our Skin?


There is a lot of talk about how taking peptides can make you look and feel younger. Well, we can delve into that later, but let's discuss the science behind this popular peptide.


Meet Your FibroBlasts:

Fibroblasts are like your repair crew for your connective tissues. It helps build our foundation of collagen, if there is an injury or tear in the connective tissue.


Fibroblasts will lay down new collagen and also coordinate cleanup so the area can rebuild. They can also act as little winches, pulling the wound's edges together for healing.


BPC-157 appears to possibly stimulate fibroblast activity/collagen expression.


Therefore, BPC-157 may help your body repair itself after an injury or overuse.

  • There may be some crossover for recovery from exercise/post-workout, but the primary studies point to accelerated healing from injury.
  • It could even be beneficial in post-surgery recovery.
  • It can also be helpful in tendon-to-bone re-connection and bone healing after injury.

Gut-Health:

BPC-157 shows promise for the stomach and gut lining. Helping the stomach and gut lining heal from ulcers and gastritis. Additionally, this may/could also be beneficial for individuals with ulcerative colitis, inflammatory bowel conditions, and those experiencing intestinal barrier dysfunction (leaky gut).

How is BPC-157 Taken?

In clinics and retail, you will see injections and oral routes for administering this peptide.

  • Oral capsules are common, but there is mixed speculation that BPC-157 can survive the gastric juices.
    • Since BPC-157 was initially identified in the stomach, it is believed that it can be administered orally as a capsule.
    • Evidence is limited, as there are few studies on humans and most are extrapolated from animal studies. But there are numerous anecdotal reports of benefits.
    • There is hope that taking it orally could be very beneficial for people with GI issues.
  • Injection appears promising for healing injuries, particularly tendons and ligaments, due to its potential to stimulate fibroblasts and promote collagen formation.

Later in this article, I will provide more specific information on dosing, but let's first learn about another popular peptide, TB-500.

TB-500 (Thymosin Beta 4)

TB-500 is similar to BPC-157 in that it can help with wound and injury healing. There is even thought that it can help with eye health, heart health, and even brain health. Not to mention, there is thought that it can help with hair loss, recovery after strokes, and dementia.


Wow, TB-500 sounds like the panacea for everything aging, right?

Now, remember this is mainly based on animal models. But let's get to know TB-500 a little more.

  • Thymosin Beta 4 is a 43-amino acid peptide that helps cells move, survive, and rebuild tissues after an injury.
    • TB-500 is a 7-amino acid fragment derived from Thymosin Beta 4
  • It helps turn on repair programs and rebuild tissue.
    • It does this by acting on actin (no pun intended).
    • Actin is the track that repair cells can move on to migrate to a site that needs repair.
    • Think of your repair cells as cars, and actin as the road that leads to the site of injury for healing and cleanup.
  • Helps to build micro-blood vessels. This can help bring in more oxygen and nutrients for the healing process. Additionally, it may help clean up metabolites.
  • Promising role in eye health as seen with studies of Thymosin Beta 4.
    • Reducing inflammation.
    • Speed up the healing of the cornea (as seen with Thymosin Beta 4)
    • It could help with dry eye (as seen with Thymosin Beta 4), a common symptom that occurs after menopause when estrogen levels drop.

How Do You Take TB-500? Overview:

  • Topical Eye Drops:
    • You can take TB-500 as eye drops to possibly help with eye health. If you use it as a topical eye drop, it will not migrate systemically to help your entire body, but could be more focused on your cornea and eye health.
  • Injections: This shows the most promising effect when viewed from a systemic perspective.
  • No oral capsules.
    • It is a large peptide with 43 amino acids; it is highly likely to be broken down by your gastric juices, making oral availability very low.
  • No topical effect.
    • Because TB-500 is a large peptide, it is unlikely to permeate the skin when applied topically.

Later in this article, I will delve into the specifics (dosing and phases) for IM and SubQ for TB-500.

Too Good To Be True?

Well, BPC-157 and TB-500 are not FDA-approved, which is also true for supplements.

However, concerns exist about the quality and potential impurities, depending on where you purchase these peptides.


And your immune system could react to the peptide itself, or even the contaminants, to cause an allergic reaction. Because our immune system has such an excellent memory, the next time you come into contact with an allergen, it could make an even worse reaction.


Additionally, the studies have been limited to animal studies, with few human studies available. These benefits and possible positive effects are primarily extrapolated from animal studies and anecdotal reports (as of September 2025).

This is the main critique: that the primary studies are animal-based, with limited human studies, and it is not FDA-approved.


Athletes Don't Dope: The idea of a speedier recovery from an injury sounds amazing for anyone, especially athletes. But under anti-doping rules, any non-approved drug is banned at all times.


So athletes should always check the current WADA List/USADA resources. Currently, BPC-157 and TB-500 are prohibited completely. Even if a small amount is detected in your system as a competing athlete, you are disqualified and could be penalized.


Again, BPC-157 and TB-500 are not FDA-approved and technically cannot be prescribed for human treatment, as in treatment for a condition, disease, or diagnosis. But it can be sold as 'intended for research purposes only' and not for personal use. That is usually how it is sold, as research-only to the public.


How do you take BPC-157 and TB-500, and what is the process of stacking them?

Let's delve into the specifics of dosing these peptides. However, first, stacking involves combining both BPC-157 and TB-500, with the idea that this approach may yield improved effects on tissue repair and recovery.


Why Take BPC-157:

  • Injuries such as sprains, muscle tears, tendon/ligament strains.
    • Think sprained ankles, rotator cuff injuries.
  • Post Surgery to help speed up recovery and healing
  • Gut Issues:
    • Inflammatory bowel conditions such as Crohn's/ulcerative colitis seem promising.
    • Leaky gut
    • Gastritis, stomach ulcers
  • Bone Density: There is thought that BPC-157 could help with bone density, and help with healing bone fractures
  • Joint: Possibly could help with inflammation of joints, such as arthritis. I can't wait to see if there is more info or studies in the future for osteoarthritis, which could be really impactful.
  • Nerve Repair: Although this is preliminary, there is some evidence that BPC-157 may help with nerve injuries and brain health, potentially including traumatic brain injury (TBI).

In the paid version of this article, learn:

  • How BPC-157 and TB-500 are commonly taken
  • Differences between oral vs. injection routes
  • What a typical BPC-157 cycle looks like
  • What a typical TB-500 cycle looks like
  • How some people stack the two for injury recovery, chronic joint pain, and exercise repair.


Peptide therapy is new, exciting, controversial, speculative, and perhaps on the latest cutting edge of medicine. This is the beginning of how peptides can help with not just anti-aging and longevity, but also reducing or preventing chronic conditions. I am sure down the road or even months from now, I will re-read this article and realize how much more there is to peptide therapy, with how fast it is advancing.

-Dr. Valorie Davidson

Ps: Not FDA-approved. Experimental; quality and dosing vary by source.
Do NOT use if pregnant, trying to concieve, or breastfeeding. Avoid with active cancer or history of cancers where angiogenesis/hormones are a concern. Medical conditions—use with caution: liver/kidney disease, autoimmune flares, bleeding disorders, prior severe injection/site reactions, or known allergies to peptide/excipients. Injection safety: sterile technique only; never inject through skin infection/irritation.
Supervision & sourcing: work with a reputable clinician, verify purity, and have a clear stop plan for adverse effects.
This is educational, not medical advice.

The full article is only available for paid subscribers. Upgrade to unlock the full article.

Upgrade to the full newsletter here and get the rest of the story.

Simon Says:

Simon says

Welcome to the cold and flu season.

Dose yourself up with vitamin D.

Whether it is supplementation (check your levels first), or getting outside for the fall sunshine, soak up the vitamin D.

Vitamin D can help support your immune system, making colds and flus less frequent and less severe.


GHK-Cu (Copper Tripeptide)

GLOW Stack and stacking with Estriol

For this article, I want to discuss GHK-Cu, which has been widely promoted as the new panacea for anti-aging, skin, and hair care.

Other properties are being made claims about GHK-Cu, but for this article, I am going to discuss:

  • GHK-Cu: What is it?
  • GHK-Cu: possible benefits for skin
  • GHK-Cu: possible benefits for hair
  • GLOW Stack: stacking GHK-Cu with BPC-157, and TB-500
  • Stacking with estriol for the face

GHK stands for glycyl-L-histidyl-L-lysine. GHK is a small peptide, just 3 amino acids long. GHK can bind to copper to become GHK-Cu.


GHK is naturally present in our plasma and tissues and has a high affinity for binding to copper.

GHK + Cu = GHK-Cu


GHK is present in our blood (plasma), but as I mentioned above, it is also found in our tissues.


Well, what tissues, you ask?

It is prevalent in our urine, saliva, and skin. And I say skin because it could help with repair, remodeling, and cellular turnover.


As is often the case with many things, GHK levels decrease with age.
Making GHK-Cu peptide a new anti-aging concept for our skin and hair?

What About The Copper Part?

GHK itself is not what makes our skin glowy, plump, and youthful. It's the combination of GHK with copper that is the main ingredient for skin and possibly the hair.


Copper is an essential trace mineral. But copper in the body by itself is toxic. So copper is bound by a protein called ceruloplasmin.

GHK (the peptide) loves copper. GHK will come along and whisk copper from ceruloplasmin, forming its own couple.

GHK + Cu = GHK-Cu


This is where the magic happens. GHK-Cu can help:

  • Tell tissues to repair themselves by turning on genes to make collagen, elastin, and glycosaminoglycans.
    • Which, in plain English, could help with firmer skin, tendons, and bones. Plus, more plump and resilient skin.
  • Reduce inflammation for less swelling and redness.
  • Cell protection by mopping up free radicals (reactive oxygen species) and keeping the cellular membrane strong and intact.
  • Grow new blood vessels (capillaries) for more oxygen and nutrients to cells.
  • There is some (somewhat weak) evidence to support the stimulation of hair follicle enlargement and the growth of stronger hair strands. Like I said, it's weak evidence, but still could be promising, since hair shedding can become such an issue in hormonal changes, like peri and menopause.

Before you run out and buy a bunch of copper supplements, that might not be a good idea.


As it is rare to have a copper deficiency.


Situations where your copper could be too low:

  • Copper deficiency: Not common unless there is digestive malabsorption (celiac, inflammatory bowel conditions, bariatric surgery).
  • Genetic/metabolic conditions, such as Menkes (rare).
  • Zinc Overload: With cold and flu season, a lot of people are taking zinc supplements. If you are taking too much zinc, it can crowd out copper absorption.
    • Taking high doses of zinc (greater than 50mg) for a short duration (for the immune system when sick) is very unlikely to cause copper deficiency.
    • Taking high doses of zinc continuously could deplete copper absorption. So if you are taking zinc and wondering, you can test your blood for copper.
      • Serum copper (70-140 ug/dL)
      • Ceruloplasmin (20-50 mg/dL)
      • Serum zinc to serum copper ratio (8:1 zinc:copper)

Copper Foods:

Food is medicine. Eating foods rich in copper is a great way to increase copper intake in your body.

  • Oysters and shellfish
  • Liver and organ meats
  • Nuts and seeds
  • Legumes
  • Quinoa, oats, and barley
  • Dark Chocolate
  • Potato skins
  • Spinach and kale

Now, there are numerous online sources that discuss the accolades of GHK-Cu. But for this article (to keep it reasonably sized), I am going to talk about it for skin and hair benefits.


Skin:

Recap on the benefits that GHK-Cu could help with when it comes to your skin:

  • Boosts collagen and elastin for firmer, plumper, resilient skin
  • Increase glycosaminoglycans, which are similar to hyaluronic acid, as they help the skin stay hydrated, plump, and springy.
  • Improves wound healing for cuts, burns, or procedures from lasers and microneedling.
  • It doesn't affect the production of acne. However, it may help alleviate inflammation, redness, and the healing process of the skin from acne. And it can help improve the skin barrier, which is helpful in acne.
  • Reduces inflammation
  • Build more micro-blood vessels to increase oxygen, facilitate cleanup, and deliver nutrients.
  • Reduce wrinkles: By slowing or calming Matrix Metalloproteinase (MMPs). MMPs are enzymes that chew up collagen. With excess UV (sun) pollutants and inflammation, MMPs can go into overdrive. GHK-Cu puts the brakes on overactive MMPs to slow collagen breakdown. Less collagen being degraded means smoother, plumper skin.

Hair:

While the human studies are limited, there is promise that GHK-Cu could help with hair growth, hair health, and shedding.

  • Push hair follicles toward the growth phase (anagen).
  • Reduce scalp inflammation
  • Promote the collagen around the hair follicle, which can help with better hair strand health, texture, and thickness.
  • Stronger hair strands mean less breakage.

Next, let's talk about GHK-Cu TOPICAL (for skin and hair).


GHK-Cu Topical for Skin

Many products have GHK-Cu in the formulation. This is by far the most common way to take GHK-Cu. Topically, it can penetrate the skin and have a really nice effect. Many face serums/creams and eye serums/creams contain GHK-Cu.


Which could penetrate better:

  • Serum: GHK-Cu is small and water-soluble. It would penetrate the skin better as a water-based serum.
  • Liposomes and nano-emulsions

What about creams?

  • Creams are beneficial for helping keep the skin hydrated and protecting the skin barrier.
  • Creams can be better for someone with really sensitive skin. So their skin could get used to the GHK-Cu to start.

If you want something simple, opt for a cream that contains GHK-Cu, and it's a one-stop shop.


If you use a serum, it is more of a process.

  • Cleanse→GHK-Cu serum→moisturizer→SPF (if during the day)
  • If you are also using estriol face cream. Cleanse→GHK-Cu serum→estriol cream→moisturizer→SPF (if during day)

What to Avoid (if using GHK-Cu serum or cream) or don't pair in the same routine

  • Acids: AHA, BHA, PHA (use in opposite routine)
  • Vitamin C serum (it destabilizes the peptide). Just use it in an opposite routine (vitamin C
  • AM and GKH-Cu PM). Retinoids (use in the opposite routine)
  • Benzoyl peroxide (use in the opposite routine)
  • Peels or exfoliating acids (use in the opposite routine)

When exploring brands, choose:

  • Nano/liposomal/liquid-crystal delivery, or if not, the next best is a simple water-based

GHK-Cu Topical for Hair:

Topical GHK-Cu for the hair is mainly used as a topical scalp solution. But there are also foams, creams, and sprays. These can be compounded by a compounding pharmacy or bought OTC.

  • Compounded scalp solutions that are prescription:
    • 0.5% GHK-Cu applied to the scalp once to twice daily (usually between 0.1 - 0.5%)
      • These can be made into creams, foams, and serums.
      • Some women use it several times a week because this can make their hair feel a little greasy, especially since who washes their hair every day? But using it daily does work better.
  • OTC scalp treatments are typically not medical-grade, but they can be helpful.
    • Serums or sprays
    • Once to twice daily

Now, if you have read my previous articles on hair health during perimenopause and menopause, then you know that hair growth is a complex process. There are many phases and changes that affect our scalp environment, hormones, hair follicles, nutrients, hydration, and more, all of which contribute to hair growth. If you plan to try GHK-Cu for hair, allow at least 3 to 6 months for a positive outcome to be evident.


It is common to stack GHK-Cu with minoxidil and/or finasteride. I am not recommending this, but it could be helpful.


I just want you to learn the common practice of stacking GHK-Cu that other people, clinics, and practitioners are doing. It really depends on the person and their hair 'goals' on what level of intervention they need.


I have previous articles on hair health and naturopathic treatments that

I usually start with if you are interested in that.

In the full article, learn:

  • How GHK-Cu is being combined with other treatments
  • Stacking with minoxidil and finasteride for hair
  • Injectable and oral protocols GHK-Cu
  • GLOW peptide stack with BPC-157 and TB-500
  • How to stack estriol for skin support.

These details are included in the paid version of Progress Your Hormones.


There is much more to peptides in general, and even more to GHK-Cu, TB-500, and BPC-157 than I have included in this article.


As you can see, there are many different ways people stack and take GLOW peptides. In fact, this is true for nearly all peptides.


Dosing, cycles, and delivery methods vary widely depending on the source, and I believe should be tailored to the individual.


It's essential to work with a reputable practitioner who understands the importance of sterility, purity, and individualized dosing.


So this is not the length of War and Peace; I tried to keep this as concise as possible. I will be writing more on peptides in the future. If you would like to share your experience with peptides or questions, thoughts, concerns, or your own insights, please drop me a message.


Thank you for reading,

Dr. Valorie Davidson

Ps: Not FDA-approved. Experimental; quality and dosing vary by source.
Do NOT use if pregnant, trying to concieve, or breastfeeding. Avoid with active cancer or history of cancers where angiogenesis/hormones are a concern. Medical conditions—use with caution: liver/kidney disease, autoimmune flares, bleeding disorders, prior severe injection/site reactions, or known allergies to peptide/excipients. Injection safety: sterile technique only; never inject through skin infection/irritation.
GHK-Cu specific: avoid systemic use with copper-metabolism disorders (e.g., Wilson disease) or unexplained high copper; stop if irritation/discoloration occurs. Supervision & sourcing: work with a reputable clinician, verify purity, and have a clear stop plan for adverse effects. This is educational, not medical advice.


→ Subscribe to the full version of the newsletter to read the rest.

My Menopause

If you are familiar with my writing, I talk a lot about tailoring HRT to a specific individual. It’s not a one-size-fits-all approach. Rather, getting a detailed intake, lab work, health history, hormone and health goals, and putting it all together into a beautifully detailed personalized plan.


Recently, I have been getting a lot of questions about rhythmic dosing. There are practitioners who have no idea what it is, are curious about it, and are repulsed by it.


I have women from all over the world wondering if it might be of help in their hormonal journey, what it is, and how it works.


I do rhythmic dosing HRT for myself.


I want to get more specific than I have in the past and tell you exactly what dosing I am taking daily.


Yes, I am going to tell you exactly what estradiol and progesterone doses and frequency I do myself. With that being said, this is just for educational purposes and not medical advice, talk to your practitioner…


Quick overview (bc those of you familiar with my writing know I am ‘wordy, hence the long newsletters… lol).


What is Rhythmic Dosing?


Rhythmic HRT is taking estradiol and progesterone in a dosing manner that mimics the natural ovarian cycle.


In a perfect natural cycle:


Days 1-5 period: estrogen low, progesterone non-existent

Days 6-11: estradiol levels are rising. No progesterone levels.

Day 12: estradiol levels spike their very highest level of the cycle.

Day 13: estradiol levels are still high but dropping

Day 14: ovulation: estradiol levels drop, and progesterone starts to be produced

Day 15-20: progesterone levels rising. Estradiol levels drop a little more but start leveling out.

Day 21: Progesterone is the highest of the cycle

Day 22-28: estradiol levels and progesterone start to decline until a period starts.


Why did I choose rhythmic dosing HRT for me?

When I went through menopause about 2 years ago, I noticed that I was having issues with my static dosing. I have often run up against this with many of my patients.


I knew my body needed estrogen, as my blood levels were showing on the lower side, and my FSH was starting to climb.


But my uterus was not cooperating. I would start spotting randomly and frequently. And I would get a period out of the blue.

Bleeding on static dosing is not intended. A thickened endometrial lining can be a risk factor for uterine cancer, not to mention annoying and bothersome.


I didn’t have any polyps, fibroids, or even that thick of a uterine lining. Just this random spotting and irregular periods (from 60 days to every 2 weeks).

And I would get bloated out of the blue for no reason, and random breast tenderness. I didn’t really get any hot flashes, maybe one every few weeks or a month. And the brain recall was terrible. I would drop words, and couldn't remember words. I would try to hide it by replacing words I couldn’t remember, like using lavender for the word purple.


So was I in menopause? Or was I in perimenopause?

Well, this is something I am quite familiar with after working with women’s health, hormonal health, and HRT since 2004.


I was in that ‘gray area’ of leaving perimenopause, but not quite into menopause.

I was an In-Betweener.


An In-Betweener is someone who is not quite into menopause, but also on their way out of perimenopause.

An In-Betweener falls through the cracks bc they are either treated as a perimenopausal female (not allowed any form of estrogen) or treated as postmenopausal (with way too much static estradiol given, hence the bleeding).


Now, rhythmic dosing is not for everyone. It consists of supplying physiological levels of estradiol and progesterone. In a nutshell, it is a lot of estradiol and progesterone. But it literally mimics the ovarian cycle. With the rise and fall of estrogen and progesterone, there is a way to supply the hormones without the inconsistent bleeding or risks.

Rhythmic dosing is a way to ‘capture’ the irregular bleeding and create a ‘period’ on a regular cycle.


Yes, on the rhythmic dosing, I get a period once a month, usually every 26 days. It's easy peasy and only 3 days long. I will say those months when I missed periods were kinda nice. But the worry of when I am going to start bleeding again, or the frequent spotting, was worrisome and annoying.

My HRT Dosing for Rhythmic Dosing: this is exactly what I am doing right now:


ESTRADIOL: transdermal cream I apply to my inner thigh BOTH morning and evening

Days 1-5: 4mg am and pm

Days 6-8: 6mg am and pm

Days 9-10: 7mg am and pm

Day 11: 8mg am and pm

Day 12: 12mg am and pm

Day 13: 6mg am and pm

Day 14: 4mg am and pm

Days 15-17: 3mg am and pm

Days 18 to period (which happens on 26 ot 26): 4mg am and pm

When I get my period (regardless of the day): I start over on day 1


PROGESTERONE:

I take a capsule for my rhythmic dosing. But a lot of people use progesterone cream for their rhythmic dosing. If you are interested in progesterone cream, drop me a message. Bc I am always my own guinea pig, I may do the cream at some point or next cycle, I’ll keep you posted.


Progesterone: Sustained-release capsules taken at night starting on day 14

Day 14-15: 100mg pm

Day 16-17: 150mg pm

Day 18-19: 200mg pm

Day 20: 250mg pm

Day 21: 300mg pm

Day 22-23: 250mg pm

Day 24: 200mg pm

Day 25-26: 150mg pm (then I usually start my period on the morning of the 27th)


If I didn’t get my period: 27-until period: 100mg pm (until period starts)

So, there you go, my rhythmic estradiol and progesterone dosing.

Please, if you have any comments or questions, send me a message.

Take care,

Dr.Valorie

xoxxo crabby-DrV

Disclaimer

All content found in this newsletter, including text, images, audio, video, or other formats, was created for informational purposes only. The purpose of this website and blog is to promote consumer/public understanding and general knowledge of various health topics. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concern regarding this topic, then it is time to find a new doctor.

1140 10th St Ste 212, Bellingham, WA 98225
Unsubscribe · Preferences

Progress Your Hormones Newsletter

A newsletter about hormones, HRT, and Dr. Valorie’s personal experience with menopause and rhythmic dosing.

Read more from Progress Your Hormones Newsletter

VIEW IN BROWSER Dr. Valorie November 25th, 2025 The Thanksgiving Effect In this issue What's Happening The Thanksgiving Effect Simon Says My Menopause What's Happening? Hi everyone, I’ve made a free video minicourse called The In-Betweener Minicourse. It’s for anyone who is almost out of perimenopause but not quite in menopause, where you feel stuck in the middle. This phase in life is often overlooked, misdiagnosed, and/or mistreated. If this sounds like you, just click on the link....

VIEW IN BROWSER Dr. Valorie November 25th, 2025 The Thanksgiving Effect In this issue What's Happening The Thanksgiving Effect Simon Says My Menopause What's Happening? Hi everyone, I’ve made a free video minicourse called The In-Betweener Minicourse. It’s for anyone who is almost out of perimenopause but not quite in menopause, where you feel stuck in the middle. This phase in life is often overlooked, misdiagnosed, and/or mistreated. If this sounds like you, just click on the link....

VIEW IN BROWSER Dr. Valorie November 11th, 2025 Holiday Havoc on the Liver In this issue What's Happening My Liver, What a Nag! Simon Says Katy Feels Krappy My Menopause What's Happening? This is the 17th edition of the Progress Your Hormones Newsletter! Those of you from #1 to now, I am so grateful to you all. And those of you who are new, welcome to my newsletter. A place about women’s health and longevity, HRT, menopause, perimenopause, and anything about hormonal health. Anything you want...